The concept of “flow chemistry” defines a very general range of chemical processes that occur in a continuous flowing stream, conventionally taking place in a reactor zone.

The application of flow chemistry relies on the concept of pumping reagents using many reactors types to perform specific reactions.

The most common types of reactors are plug flow reactors and column reactors, whilst for specific chemistries more sophisticated reactor designs might be needed (e.g., photoreactors, electrochemical reactors, etc).

Chimiste

Set-Up:

Figure 1 shows an example of a schemtic of a flow system.

Exemple de schéma d'un système de chimie en continu

Figure 1

A flow system includes:

a) At least one pump with good chemical compatibility,
b) Manual or automatic valves,
c) A flow path,
d) A T,
e) A coil reactor or a glass mixer block/chip reactors for homogeneous syntheses,
f) A column reactors for heterogeneous syntheses,
g) A module for heating or heating/cooling,
h) Back pressure regulators.

 

Advantages of flow chemistry:

There are well-defined key advantages using flow technologies as compared to standard batch and microwave chemistry methods.

Flow chemistry, improves heat transfer & mass transfer/mixing for faster reactions, by superheating at elevated pressure.

Exemple d’une accélération de la vitesse de réaction dans des conditions de « surchauffe à haute pression »

Flow chemistry allows:

– To have high reproducibility and scalability, for instance, continuous processing can deliver 100s g to 10 Kg per day.

Certaines synthèses en continu, peuvent fournir entre 100g à 10kg de produit par jour

– To have extreme reaction conditions (high/low temperature, high pressure).

FlowSyn PTFE FlowSyn Steel FlowSyn Hastelloy
Flow path All PTFE PTFE & 316L PTFE & HC-276
Pmax 40bar (600psi) 100bar (1450pas) 100bar (1450pas)
Tmax 150°C 300°C 300°C
Chemical resistance Excellent Very good Excellent

 

Boiling point °C @
1 bar 6.9 bar 17.0 bar
CH2Cl2
 41 109 153
MeOH 65 138 185
THF 66 140 186
iPrOH 82 159 207
MeCN 82 159 207
H2O 100 181 231
Dioxane 101 182 234
DMF 153 244 301
DMA 165 259 318

▀ Useful solvents for flow with bp exceeding 150°C

– To do multistep (telescoping),
– To have in-line downstream processing,
– To make it possible to automate,
– To improve safety and mange hazardous reagents and intermediates, small reactor volumes minimize risk associated with hazardous intermediates.

les petits volumes de réacteurs minimisent le risque associé aux intermédiaires dangereux

Innovative Advion Interchim scientific solutions

For flow chemistry applications, Advion Interchim scientific offers innovative pre-configured innovative flow chemistry platforms and modules to add to them, or to create a specific tailor-made system.

Possibilité de créer son propre système spécifique sur mesure

Innovative pre-configured flow chemistry plateforms

 

Manual control : FlowLab™

FlowLab Uniqsis

Entry level flow chemistry system

  • 2 x HPLC pumps with pressure transducers and manual inlet selection valves; 0.01 to 10.0 mL/min, Pmax =100bar (2 each)
  • HotCoil reactor station ambient to 260°C (300oC option)
  • Coil reactors: 5.0mL stainless steel and 5.0mL PTFE Vcoil reactors (1 each),
  • Laptop with FlowLab control application installed
  • PTFE “T”-piece mixer and connecting tubing
  • 100psi fixed back pressure regulator and PEEK holder
  • Bottles and caps
  • Ethernet Hub and Wi-Fi router

 

Automated control : FlowLab™ Plus

FlowLab Plus Uniqsis

Modular flow chemistry system

  • 1 x HPLC binarie pumps with pressure transducers and manual inlet selection valves; 0.01 to 10.0 mL/min, Pmax =100bar (2 each)
  • Polar Bear Plus Flow cryogenic reactor station –40°C to 150°C
  • 5.0mL and 14.0mL PTFE HT coil reactors (1 each),
  • Laptop with FlowLab control application installed
  • PTFE ‘T’-piece mixer and connecting tubing
  • 100psi Fixed BPR cartridge and PEEK holder
  • Bottles and caps
  • Ethernet Hub and Wi-Fi router

 

Integrated flow reactor : FlowSyn™ & FlowSyn™ Multi X

FlowSyn Uniqsis

Integrated flow chemistry system: FlowSyn™

  • Carry out superheated reactions up to +260°C and 100bar
  • Wide range of coil, chip and column reactors available in a variety of materials for optimal chemical compatibility
  • Automated, chemically resistant sample injection valves
  • Seamlessly scale up reactions up to and 100mL/min (FlowSyn Maxi)
  • Choose flow path from PTFE, 316L stainless steel or Hastelloy C
  • Future proof – numerous hardware and software upgrade options available for maximum flexibility
  • Fully integrated systems for total ease of use

 

FlowSyn Multi X Uniqsis

Integrated flow chemistry system: FlowSyn™ Multi X

  • Automatically runs up to 10 sequential experiments
  • Vary reaction temperature, residence time and stoichiometry
  • Choice of ‘optimization’ or standard ‘fractionation’ protocols
  • Integrated control interface – no need for a separate PC
  • Single and 4 rack fraction collector options
  • Compact footprint
  • Automated sample loop injection valves for compound library synthesis

 

FlowSyn™ Auto-LF - 2 or 4 channel system

Integrated flow chemistry system: FlowSyn™ Auto-LF – 2 or 4 channel system

  • Automate experiments with multiple combinatorial reagent inputs
  • Powerful intuitive PC interface for real-time reaction monitoring and data logging
  • Stacked, small format XYZ sampler/fraction collector minimizes space requirements
  • In-built automated wash protocols
  • No unreliable sample injection ports
  • Septum-piercing liquid handling ensures reagent solutions are preserved
  • Air bubbles prevent sample dispersion when loading sample loops to minimize reagent wastage
  • System shown includes optional inline UV/Vis detector

 

Modules for innovative pre-configured flow chemistry platforms and bespoche systems

Schéma Modules additionnels pour les plates-formes innovantes préconfigurées

Pumps

Pompe HPLC Uniqsis

Stand alone Pump Module

  • HPLC pumps: Pmax = 100/200bar
  • Flow rates: FRmax =10mL/min or 50mL/min (Maxi)
  • 4 way inlet valve
  • Built in pressure transducer 100/200bar

 

Binary Pompe Uniqsis

Binary Pump Module

  • 2 x HPLC pumps: Pmax = 100bar
  • Flow rates: FRmax = 20mL/min or 100mL/min (Maxi)
  • 2 x High pressure injection valves
  • Stainless steel, PTFE or Hastelloy® flow path options

 

Syringe pump

Syringe Pump

  • Syringe pump, holds 1 Syringe from micro-liter sizeq up to 60mL (140mL partially filled)
  • Infusion rates from 0.73µL/hr (1mL syringe) to 2100mL/hr (60mL syringe)
  • Easy-to-use keypad interface

 

Reactors

Réacteurs bobine

Coil reactors

  • Wide selection of coil reactors
  • Sizes: 2.0mL to 60mL
  • Materials; PTFE, PFA, 316L SS, Hastelloy C, Copper
  • 1/16″ or 1/8″ tubing options available, thin and thick wall optionss

 

Réacteurs colonne

Column reactors

  • Selection of Omnifit glass column reactors
  • Sizes: 10mm, 15mm, 20mm OD x100mm
  • Adjustable plunger, PTFE/PEEK construction (Tmax = 150°C)
  • Stainless steel

 

Support pour réacteurs colonne

HotColumn

  • Multi-position (6) column reactor adaptor
  • Fits all Uniqsis coil reactor modules
  • Coil reactor heater: RT – 300°C
  • Accommodates 10, 15 and 200mm OD reactors

 

Réacteurs verre

Glass Reactors

  • Static glass mixer – can also used as reactors
  • Made from borosilicate glass with pre-tempering channels and extended mixing domain.
  • Temperature range -80°C to 260°C
  • Can withstand up to 40bar
  • “Easy” standard HPLC screw connectors with Perlast ‘O’-ring sealing system
  • Different sizes (1.6, 1.0 an 0.27mL)
  • 2 input [A+B] and 3 input [(A+B)+C] option
  • Residence time chips available 15mL and 20mLmax=150°C)

 

Modules to heat or heat/cool

HotCoil Uniqsis

HotCoil

  • Coil rector heater: RT -300°C
  • Fits all FlowSyn coil reactors
  • Simple “push-to-set” rotary controller
  • Large bright LED display
  • Use as an add-on rector capacity for easy scale-up

 

HotChip Uniqsis

HotChip

  • Ambient to 200°C
  • Fits 2 small or 1 large chip (20mL)
  • Ethernet comms
  • Excellent temp control ±0.5°Cmax=150°C)

 

Polar Bear Plus

Polar Bear Plus

  • State-of-the-art heating and cooling reactor module
  • Range: -40°C – 150°C
  • Compact and easily portable
  • No card-ice or liquid N2
  • Compatible with all FlowSyn coil & “chip” reactors

 

Modules to cool

Cold Coil Uniqsis

Cold Coil

  • Requires separate recirculating chiller
  • Range: -80°C – 180°C
  • N2 gas purge to prevent “frosting up”
  • Compatible with all FlowSyn coil & “chip” reactors
  • Coil and “chip” clamping mechanism for optimal thermal contact

 

Polar Bear Uniqsis

Polar Bear

  • Self-contained cooling ractor module
  • Range: -88°C – ambient
  • No card-ice or heat transfer fluids
  • Compatible with all FlowSyn coil & “chip” reactors

 

Flow Photochemistry

PhotoSyn Uniqsis

PhotoSyn

  • 365nm, 455nm, 550nm and HP “white” LED light options
  • Independent external temperatrure control of coil reactor
  • Reflective chromed coil reactor mandrels
  • Long lifetime, water-cooled, curved LED arrays concentrate
  • Light onto the central coil reactor
  • Maximum PFA/FEP coil reactor volume 50mL
  • Safety interlocks prevent light leakage when operating

 

Lucent360

Lucent 360™

  • Flow photochemistry ssytem with unparalleled Light Configuration and Control
  • Flow reactors
  • Efficient temperature controlled from 0°C to 80°C
  • Pre-set your favorite experiments for quick repeatability

 

Flow Electrochemistry

Ammonite 8 Electrochemical Flow Cell

Ammonite 8™ Electrochemical Flow Cell

  • Suitable for flow rates up to 5mL/min
  • The cells are suitable for electrosynthesis using solutions with only a low electrolyte solution
  • High selectivity demonstrated in a variety of electrosyntheses
  • High single pass conversion for enhanced throughput
  • Spiral flow path engineered to maximise pathlength/size ratio
  • Wide range of electrode materials available
  • Throughput of several grams per hour is possible
  • Larger scale Ammonite15 also available.

 

Gas module additions

GAM-I pré-saturation module

GAM-I pre-saturation module

  • Compatible with a wide range of:
    – Reactive gases (e.g. CO, CO2, H2, D2, ethene,ethyne, SO2)
    – Organic solvents (e.g. THF, MeCN, MeOH, PrOH)
  • Perform heterogeneous and homogeneousgas-liquid reactions such as hydrogenation, ozonolysis, carbonylation, and direct synthesis of carboxylic acids

GAM-II gas-liquid coil reactor

GAM-II gas-liquid coil reactor

  • Compatible with a wide range of:
    – Reactive gases (e.g. CO, CO2, H2, D2, ethene,ethyne, SO2)
    – Organic solvents (e.g. THF, MeCN, MeOH, PrOH)
  • Perform heterogeneous and homogeneousgas-liquid reactions such as hydrogenation, ozonolysis, carbonylation, and direct synthesis of carboxylic acids

GAM-II gas-liquid coil reactor uniqsis

Teflon® AF-2400 Gas Permeability [cB]

Gas Teflon® AF-2400 PTFE
CO2 280,000 1200
O2 99,000 420
H2 220,000 980
N2 49,000 140

 

Bottles, tubing, T, fittings, valves, BPR

Catalogue Chromatographie

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