Since the end of December 2019, a new coronavirus (named nCov-2019) from Wuhan is spreading rapidly in China and the rest of the world. Preventing this spread is achieved by quarantining and screening potentially infected people.
Identification of the viral strain of this coronavirus
|Chinese scientists have now sequenced the viral genome and made its sequence available to assist the scientific community with rapid vaccine development .
This coronavirus appears to be a group 2B coronaviruses (only the alpha and beta coronaviruses have the capability of infecting humans) and shares 70% similarity to SARS-related bat coronavirus
The main coronavirus proteins of nCoV-2019
The nucleocapsid protein (N protein)
The nucleocapsid protein (N protein) is the most abundant protein in coronaviruses. Highly immunogenic, this phosphoprotein is very well conserved across coronavirus families. It is often used as a marker in diagnostic tests. The strong homology (nearly 90%) between nCoV-2019 and SARS nucleocapsid (N) proteins would allow the use of SARS N protein specific antibodies for nCoV-2019 diagnostic tests.
The spike protein (S protein)
|The spike protein (S protein) mediates receptor binding and fusion of viral and cell membranes. The spike protein contains two subunits, S1 and S2. S1 contains a receptor binding domain (RBD), which is responsible for recognition and binding to the cell surface receptor. The S2 subunit is the “stem” of the structure, which contains other basic elements necessary for membrane fusion. The spike protein is the common target of neutralizing antibodies and vaccines.|
Interchim®, through SinoBiological, is now able to offer you cDNA clones, proteins specific to nCOV-2019. Primary antibodies specific to nCov-2019 will soon be added to the existing offer.
We provide recombinant proteins include the complete S protein (ECD), S1 subunit, S2 subunit, RBD S1 and N protein. All corresponding references are listed in the following table:
|40589-V08B1||2019-nCoV Spike Protein (S1+S2 ECD, His tag)||2019-nCoV||Baculovirus-Insect Cells||C-His|
|40591-V05H1||2019-nCoV Spike Protein (S1 Subunit, mFc Tag)||2019-nCoV||Human Cells||C-Fc|
|40592-V05H||2019-nCoV Spike Protein (RBD, Fc Tag)||2019-nCoV||Human Cells||C-Fc|
|40588-V08B||2019-nCoV Nucleocapsid Protein (His tag)||2019-nCoV||Baculovirus-Insect Cells||C-His|
|40591-V08B1||2019-nCoV Spike Protein (S1 Subunit, His tag)||2019-nCoV||Baculovirus-Insect Cells||C-His|
|40591-V08H||2019-nCoV Spike Protein S1 (His Tag)||2019-nCoV||Human Cells||C-His|
|40590-V08B||2019-nCoV Spike Protein (S2 ECD, His tag)||2019-nCoV||Baculovirus-Insect Cells||C-His|
|40591-V02H||2019-nCoV Spike Protein S1 (Fc Tag)||2019-nCoV||Human Cells||C-Fc|
|VG40588-UT||2019-nCoV Nucleoprotein / NP ORF mammalian expression plasmid
|VG40589-UT||2019-nCoV Spike ORF mammalian expression plasmid (Codon Optimized)||2019-nCoV|
|VG40590-UT||2019-nCoV Spike(S2) ORF mammalian expression plasmid (Codon Optimized)||2019-nCoV|
|VG40591-UT||2019-nCoV Spike(S1) ORF mammalian expression plasmid (Codon Optimized)||2019-nCoV|
|VG40592-UT||2019-nCoV Spike(RBD) ORF mammalian expression plasmid (Codon Optimized)||2019-nCoV|